While in Group F, England have all but qualified and will make certain of their place in Russian Federation next summer with a win over Slovenia at Wembley on Thursday night.
Wales enter the final stretch of Group D without injured Real Madrid star Gareth Bale and Chris Coleman's men have an arduous return journey from Tbilisi to contend with compared to Ireland's short flight to Cardiff on Sunday afternoon.
Here's what Charlie is predicting for the five clashes.
Harry Kane scored deep into stoppage time to help England also claim their place at the World Cup with a 1-0 win against Slovenia in Group F. Maximum points could even see them pip Serbia to top spot should they lose to Austria as well as Georgia. If they finish second by winning both games, Ireland will have 13 points to their name in the play-off table.
Southgate is under pressure and we don't know what formation or system he wants to play. Two wins from two is the minimum requirement for the Dragons.
Golf star McIlroy said Keane snubbed him for an autograph when he was a kid, but O'Neill joked that he is sure one can be arranged for the golfer.
It was just Ireland's third goal of the campaign at the Aviva Stadium, where draws have proved costly, but they did not have to wait too much longer for the fourth when Wes Hoolahan picked out Ward with an exquisite cross-field pass. Meanwhile, Moldova shouldn't cause them any problems at the back. "But I definitely think that he is a goalscorer", he added.
Asked if he felt his near-four-year reign to date could be considered successful, regardless of how the ongoing qualification bid pans out, the manager replied: "Well, we qualified for a competition - one out of one".
The former Celtic boss, who guided the Republic to last summer's Euro 2016 finals, told FAI TV: "I spoke to John very recently and he said on behalf of the board he would like to extend my contract for another couple of years, obviously with the Euros coming up, and I've agreed to do so".
I would be looking to give Ben Woodburn a start after being so influential in his last two games but Hal Robson-Kanu could be the hero.
Robert Lewandowski struck a hat trick to become Poland'sleading goal scorer of all-time, overtaking Wlodzimierz Lubanski's 48 goals and helping to seal a 6-1 win over Armenia that puts them on the brink of qualification from Group E.
On the ground, Ezekiel Elliott rushed 85 yards and a touchdown in 21 carries while Alfred Morris added 76 yards in two attempts. On third-and-20 with 12 seconds left, Rodgers rolled left on a designed play against a two-deep zone with six defensive backs.
In a meeting with the military leaders, Trump emphasised that Iran must not be allowed to obtain the nuclear weapons. Confused and surprised reporters pried for more information, asking what "storm" he might be implying.
Cardinal Pell is accused of historical assaults involving "multiple complainants", police in the state of Victoria have said. Cardinal George Pell will face a four-week committal hearing next March as he fights historical sexual offence allegations.
The change allows companies and insurers to opt out of the free coverage "based on [their] sincerely held religious beliefs". The new exemptions are being praised as a major victory for religious conservatives, with the U.S.
He's in a good moment as well in terms of his form. "Let's focus a little bit more on that rather than the negatives". We have to show the resilience that whatever the atmosphere and whatever the feeling, our job is to get the result .
In response to a tweet asking whether he could rebuild Puerto Rico's electrical grid with solar, Musk said, basically, yes. Tesla Inc shares were trading at $354.01 per share on Friday morning, down $1.32 (-0.37%).
Now some automakers already ban some features from being used when the vehicle is moving. Some drivers were distracted for almost 40 seconds while programming navigation.
Trump somber in visit to stricken Las Vegas
Trump held a moment of silence on the White House South Lawn after the Las Vegas attack and ordered flags lowered to half-staff. Trump later tweeted a video of him meeting the victims of the shooting at the University Medical Center of Southern Nevada.
Putin receives Saudi King Salman during historic visit
Billboards have been erected on the road from the airport to central Moscow welcoming King Salman in Arabic and Russian. A memorandum of understanding has been reportedly signed to help the kingdom develop its own defense industries.