Saturday, 21 October, 2017

Dubochet, Frank, Henderson Awarded 2017 Nobel Prize in Chemistry

Noble Chemistry Prize Nobel chemistry prize awarded for molecular machines which repair damaged DNA
Cecilia Poole | 05 October, 2017, 00:38

The technology has huge potential in the field of biochemistry.

The prizes are named after Alfred Nobel, the inventor of dynamite, and have been awarded since 1901 for achievements in science, literature and peace, in accordance with his will. By 1990, the scientist published an atomic-resolution model of the protein. The use of both techniques was, however, subject to limitations imposed by the nature of biomolecules.

Henderson was frustrated that x-ray crystallography, which requires samples to stay in rigid formations, wasn't representative of biomolecules' dynamic structures. And NMR worked for only a relatively small set of proteins.

STOCKHOLM, Oct. 4 (Xinhua) - Three scientists have shared 2017 Nobel Prize in Chemistry, the Royal Swedish Academy of Sciences announced on Wednesday.

"This discovery is like the Google Earth for molecules in that it takes us down to the fine detail of atoms within proteins", says Campbell. And a reduction in the intensity of the beam means a substantial loss in contrast, and the image becomes fuzzy.

"Jacques Dubochet added water to electron microscopy".

"By solving more and more structures at the atomic level we can answer biological questions, such as how drugs get into cells, that were simply unanswerable a few years ago", Jim Smith, science director at the London-based biomedical research charity Wellcome, said in a statement. But in the 1970s Dubochet showed that adding water to electron microscopy in a certain way that prevented that.

This was in 1975.

Called cryo-electron microscopy, the imaging technique freezes biological molecules in place and reveals their inner workings.

"Joachim Frank made the technology generally applicable". This not only sharpened the 2-dimensional images but also allowed them to be combined into a 3-dimensional structure.

Frank's image analysis for 3D structures.

Dubochet was the first in the 1980s to successfully vitrify water, cooling it so quickly with ethane that had been chilled by liquid nitrogen that it formed a kind of glass instead of natural ice crystals.

"I think this is a very exciting choice", Jeremy Berg, editor in chief of Science and former director of the National Institute for General Medical Sciences at the National Institutes of Health, told STAT. Cryo-EM "is truly revolutionizing biochemistry, particularly over the past five years".

A trio of Swiss, American and British scientists won the 2017 Nobel chemistry prize on Wednesday for developing cryo-electron microscopy, allowing researchers to see biological molecules frozen in action.

Recommended

  • If You Had A Yahoo Account In 2013, You've Been Hacked

    If You Had A Yahoo Account In 2013, You've Been Hacked

    HACKERS stole personal data from all three billion Yahoo user accounts during a cyberattack in 2013, the tech giant has revealed. After the hack in 2013, Yahoo conducted an investigation and then disclosed the insights in 2016 .
    Iran, Turkey agree to work together to ease tension in Middle East

    Iran, Turkey agree to work together to ease tension in Middle East

    Turkey is honest in voicing opposition to Iran's some policies, particularly in Syria, Iraq, and Gulf region, Cavusoglu said. They have agreed to increase economic cooperation as well as joining forces to address major issues in the Islamic world.
    Pauley Perrette announces 'NCIS' departure after 15 seasons

    Pauley Perrette announces 'NCIS' departure after 15 seasons

    With Perrette's departure, NCIS will only feature three original cast members: Mark Harmon , Sean Murray , and David McCallum . The 48-year-old actress broke the news in a tweet sent early Wednesday.
  • NBA All-Star Game to ditch East vs. West format in 2018

    NBA All-Star Game to ditch East vs. West format in 2018

    Coaches will select the reserves - two guards, three front-court players and two players from any position. The leading vote-getters will be the team captains and they'll pick from a pool of players.
    Leicester City, Man United set for Bengaluru EPL Live

    Leicester City, Man United set for Bengaluru EPL Live

    However, they have dismantled their opponents so far with a mixture of classical Jose Mourinho defending and brute power up front. This is the team that the fans have been craving for since the Red Devils last lifted the Premier League title in 2013.
    Samsung Odyssey Windows Headset Price Revealed On Microsoft's Website

    Samsung Odyssey Windows Headset Price Revealed On Microsoft's Website

    All of the aforementioned Windows Mixed Reality-compatible headsets are available for pre-order and the links are given below. The company said that there are 20,000 Windows apps available in the Windows app store that you can use in VR or AR.
  • Amanda Seyfried and the Mean Girls Cast Raise Money for Las Vegas

    Amanda Seyfried and the Mean Girls Cast Raise Money for Las Vegas

    Peek the pics below, and get ready to get schooled by the Mean Girls musical at the August Wilson Theatre . The main idea is to raise money for the victims and provide them all the possible assistance.
    Cheap solar energy the fastest growing new power source

    Cheap solar energy the fastest growing new power source

    With this, India will match the USA , becoming the joint second-largest growth market after China. Globally, China and India lead renewable capacity growth projections.
    Senate Intel Leaders Say Ongoing Russia Probe Has Expanded

    Senate Intel Leaders Say Ongoing Russia Probe Has Expanded

    He said they have amassed more than 4,000 pages of transcripts- yet more work needs to be done. Google and Twitter have also been invited to testify.
  • National Taco Day Deals

    National Taco Day Deals

    If you're in the mood to celebrate, here's a list of local places offering discounts on National Taco Day . You can stop in or drive-thru any participating San Antonio and surrounding area Taco BellĀ® locations.
    Jaish attacks BSF HQ, ASI, 3 terrorists killed

    Jaish attacks BSF HQ, ASI, 3 terrorists killed

    Of the other two, one entered the Subordinate Officers Mess and another barged into the administrative block. Six members of this squad are still in the Valley and may launch another attack, they said.
    Lawmakers berate former Equifax CEO over huge data breach

    Lawmakers berate former Equifax CEO over huge data breach

    Smith said he would expect Equifax to "cooperate" with "particular legislation that arises out of this horrific breach". In addition to Congressional inquiries, Equifax faces a number of state and federal probes related to the hack.

Catalan officials mull date for independence declaration Catalan officials mull date for independence declaration Puigdemont said there was now no contact between the government in Madrid and his devolved administration. Felipe's dramatic intervention late Tuesday was a gauge of tension in Spain.

Kevin Owens unleashes attack on Shane McMahon Kevin Owens unleashes attack on Shane McMahon Owens delivering the same headbutt to Shane that he gave his father and then hitting the Popup Powerbomb was a great final touch. Nakamura quickly got the upper hand on Mahal, but the Singhs jumped on him and allowed Mahal the opportunity to hit The Khallas.

State Bank of India appoints new chairman State Bank of India appoints new chairman Bhattacharya was granted a one-year extension in October 2016, to maintain continuity in leadership during the merger. His experience in project finance and large corporate would be helpful to revive loan growth.