Wednesday, 22 November, 2017

Scientists develop new regenerative tissue technology

Nano-chip promises to heal organs at a touch Groundbreaking skin patch the size of a penny can regrow organs, restore brain function, and heal wounds by injecting genetic code into the damaged area
Garry Little | 09 August, 2017, 00:14

The chip, programmed with precise genetic code or certain proteins, is positioned on the skin and a small electrical current forms channels in the tissue.

This technology may be used to fix injured tissue or restore function of aging tissue, including organs, blood vessels and nerve cells, Medicalxpress.com reported. "We have shown that skin is a fertile land where we can grow the elements of any organ that is declining", said Chandan Sen, director of Ohio State's Center for Regenerative Medicine and Cell Based Therapies.

A small electric current fires DNA into skin cells to convert them into natural cell building blocks which helps to fix the damaged areas such as arteries and even organs like the heart.

"By using our novel nanochip technology, injured or compromised organs can be replaced", said study co-author Dr Chandan Sen in a statement. "This process only takes less than a second and is non-invasive, and then you're off".

In laboratory tests on mice at The Ohio State University Wexner Medical Center, the chip was able to heal serious wounds with a single touch by converting skin cells into vascular cells. In less than a week, the technology generated blood vessels ultimately saving the leg.

While the ability to reprogram cells into being other cells is not new, this technology skips the old intermediary process that forces the skin cells to first become "pluripotent stem cells" before they can become functional cells for other organs.

The new research that was published in the journal Nature Nanotechnology is a step ahead from what people commonly know as gene therapy.

This breakthrough technology is the first time cells have been reprogrammed in a live body.
It also helped brain-injured mice recover from a stroke.

Lead author Daniel Gallego-Perez says the new technology comprises two elements: the nanotech chip created to introduce reprogrammed DNA into existing adult cells; and a "specific biological cargo" that induces the cells to change from one type to another.

According to the researchers, the technology successfully worked 98 percent of the time.

"The concept is very simple", says L. James Lee, a professor of chemical and biomolecular engineering with Ohio State's College of Engineering. For a long time researchers have tried to come up with a mechanism that could treat and even fix brain injuries. "So this is the beginning, more to come".

Since the method uses a patient's own cells and does not depend upon medication, the Researchers anticipate it to be approved for human trials by the end of the year.

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